In the 2021 EHRA Practical Guide on the use of NOACs, we suggest to consider NOAC plamsa level assessment in two different types of scenarios: emergency situations. In their letter, Mbroh and Poli make a case for using point-of-care coagulation tests (POCT) to more rapidly assess the lev el of anticoagulant in patients’ blood samples. We thank the authors for addressing this important issue.1 Indeed, the assessment of NOAC plasma levels -or potential alternatives-in special situations may represent an important element in the further refinement of non-vitamin K antagonist oral anticoagulant (NOAC) therapy. (Source: Europace)Ģ021 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: comment -Authors’ reply Our group has been involved in studies on point-of-care coagulation testing (POCT) in acute stroke p atients where rapid decision-making with respect to thrombolysis and anticoagulation reversal is vital. We have read with keen interest the updated practical guide by Steffelet al.1 For safer decision-making, we share the authors ’ view on the need for rapid assessment of anticoagulation in patients under non-vitamin K antagonist oral anticoagulant (NOAC) during emergencies such as bleeding and urgent surgical intervention. by dose reduction in case of higher than expected levels or by dose inc rease in case of lower than expected levels, improve the overall benefit of non-vitamin K antagonist oral anticoagulants during long-term treatment in.Ģ021 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: comment In the section of ‘Potential indications for NOAC plasma level measurements’ of this article, the authors say that no studies have investigated if measurement of drug levels and dose adjustment based on laboratory coagulation parameters, e.g. This article indicates that anti-FXa chromogenic assays are available to measure plasma concentration of the FXa inhibitors using validated calibrators. Source: Europace - SeptemCategory: Cardiology Source Type: researchĭose adjustment based on the plasma level measurement used anti-FXa chromogenic assay on the use of non-vitamin K antagonist oral anticoagulants (NOACs) improved the overall benefit of NOACs dosing in patients with atrial fibrillation measured plasma levels in both patients on rivaroxaban and apixaban and found acceptable peak plasma levels even in a substantial proportion of patients with off-label dose reductions. Based on our 2018 EHRA Practical Guide ’s recommendations,3 Suwaet al. We thank the authors for alerting us to their recently published article on non-vitamin K antagonist oral anticoagulant (NOAC) plasma level assessments.1 Indeed, despite extensive literature review, this interesting and important article has slipped our attention.2 We like to congratulate the authors for their detailed and well-represented work. This searches for items where "Journal of the American College of Cardiology" is listed as the source.ĭose adjustment based on the plasma level measurement used anti-FXa chromogenic assay on the use of non-vitamin K antagonist oral anticoagulants (NOACs) improved the overall benefit of NOACs dosing in patients with atrial fibrillation: Authors ’ reply "Journal of the American College of Cardiology" This searches for items where the word 'heart' exists in all of the headline, description and tags fields.Įg3. This searches for the phrase 'kidney cancer' in the title as well as either the word 'trial' or 'trials' in description.
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